BDBM26697 7-chloro-9-ethyl-6-fluoro-1H,3H,4H,9H-quinolino[2,3-c][1,2]oxazole-3,4-dione::CHEMBL468280::Isoxazoloquinolinedione, 1

SMILES CCn1c2noc(=O)c2c(O)c2cc(F)c(Cl)cc12

InChI Key InChIKey=GOKWYLQQNCJARE-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26697   

TargetSerine/threonine-protein kinase pim-1(Human)
Abbott Laboratories

LigandPNGBDBM26697(CHEMBL468280 | 7-chloro-9-ethyl-6-fluoro-1H,3H,4H,...)
Affinity DataKi:  21.8nM ΔG°:  -10.3kcal/molepH: 7.5 T: 2°CAssay Description:Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Abbott Laboratories

LigandPNGBDBM26697(CHEMBL468280 | 7-chloro-9-ethyl-6-fluoro-1H,3H,4H,...)
Affinity DataKi:  22nMAssay Description:Inhibition of Pim1 assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Abbott Laboratories

LigandPNGBDBM26697(CHEMBL468280 | 7-chloro-9-ethyl-6-fluoro-1H,3H,4H,...)
Affinity DataKi:  174nM ΔG°:  -9.12kcal/molepH: 7.5 T: 2°CAssay Description:Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed