BDBM278941 4-{8-amino-3- [(6R,8aS)-6-methyl-3- oxohexahydro[1,3] oxazolo[3,4-a]pyridin-6- yl]imidazo[1,5- a]pyrazin-1-yl}-3- ethoxy-5-fluoro-N-[4- (trifluoromethyl) pyridin-2-yl] benzamide::US10040805, Example 11

SMILES CCOc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc(F)c1-c1nc([C@]2(C)CC[C@H]3COC(=O)N3C2)n2ccnc(N)c12

InChI Key InChIKey=KSGNUSPSHBOAMI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278941   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 278941BDBM278941(4-{8-amino-3- [(6R,8aS)-6-methyl-3- oxohexahydro[1...)
Affinity DataIC50: 0.590nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent