BDBM3149 2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid::Acyclic Balanol Analog (-)-1::Balanol analog 1::Balanol, 1::CHEMBL60254

SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1

InChI Key InChIKey=XYUFCXJZFZPEJD-UHFFFAOYSA-N

Data  2 KI  110 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 116 hits for monomerid = 3149   

TargetProtein kinase C alpha type(Human)
University of California At San Diego

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 0.0740nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to human recombinant N-terminal GST-tagged PKGalpha expressed in Baculovirus infected insect Sf9 cells using RKRSRAE as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataKd:  1.80nMAssay Description:Binding affinity to PKCbeta2 (unknown origin) using Lys-Arg-Thr-Leu-Arg-Arg as substrate after 8 mins in presence of [gamma-32P]ATP by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Protein kinase C etaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProtein kinase C eta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Protein kinase C etaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProtein kinase C eta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 3nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2005
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Protein kinase C etaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProtein kinase C eta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C eta isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human PKAC-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataKd:  3.90nMAssay Description:Binding affinity to PKAalpha (unknown origin) using Lys-Arg-Thr-Leu-Arg-Arg as substrate after 8 mins in presence of [gamma-32P]ATP by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Protein kinase C deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetcAMP-dependent protein kinase catalytic subunit gamma(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProtein kinase C delta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 4nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C delta isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PKCeta (unknown origin) by IMAP kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-dependent protein kinase(Rabbit)
University of California San Diego

LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataKi:  4.70nM ΔG°:  -11.5kcal/molepH: 7.5 T: 2°CAssay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2011
Entry Details Article
PubMed
TargetProtein kinase C beta type(Rat)
University of California San Diego

LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataKi:  5.30nM ΔG°:  -11.5kcal/moleT: 2°CAssay Description:Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2011
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
University of California At San Diego

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataKd:  6.40nMAssay Description:Binding affinity to PKCalpha (unknown origin) using Lys-Arg-Thr-Leu-Arg-Arg as substrate after 8 mins in presence of [gamma-32P]ATP by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C epsilon isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProtein kinase C gamma type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProtein kinase C gamma type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProtein kinase C beta type(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C beta 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProtein kinase C beta type(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2005
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2005
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C beta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProtein kinase C beta type(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C beta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProtein kinase C gamma type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2005
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C beta 1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C epsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProtein kinase C beta type(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C beta 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProtein kinase C beta type(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C beta 2 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C beta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProtein kinase C beta type(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C beta 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProtein kinase C delta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 16nMAssay Description:Inhibition of Protein kinase C deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProtein kinase C delta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 16nMAssay Description:Inhibition of Protein kinase C deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProtein kinase C eta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human Protein Kinase C etaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetProtein kinase C epsilon type(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 20nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2005
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Protein kinase C epsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProtein kinase C epsilon type(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Protein kinase C epsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProtein kinase C eta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 20nMAssay Description:Inhibition of protein kinase C etaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetProtein kinase C eta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 20nMAssay Description:Inhibition of protein kinase C etaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetProtein kinase C delta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 20nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2005
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 20nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C gamma isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 22nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2005
Entry Details Article

TargetProtein kinase C eta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 22nMpH: 7.5 T: 2°CAssay Description:The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2005
Entry Details Article

TargetProtein kinase C eta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 22nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2005
Entry Details Article

TargetProtein kinase C delta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 23nMAssay Description:Inhibition of protein kinase C deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetProtein kinase C delta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 23nMAssay Description:Inhibition of protein kinase C deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetProtein kinase C gamma type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 30nMAssay Description:Inhibition of protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetProtein kinase C beta type(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 30nMAssay Description:Inhibition of protein kinase C beta IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

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