BDBM3149 2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid::Acyclic Balanol Analog (-)-1::Balanol analog 1::Balanol, 1::CHEMBL60254
SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
InChI Key InChIKey=XYUFCXJZFZPEJD-XMSQKQJNSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 114 hits for monomerid = 3149
Affinity DataKi: 4.70nM ΔG°: -11.5kcal/molepH: 7.5 T: 30°CAssay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 5.30nM ΔG°: -11.5kcal/moleT: 30°CAssay Description:Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.More data for this Ligand-Target Pair
Affinity DataIC50: 74nMpH: 7.5 T: 30°CAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 32nMpH: 7.5 T: 30°CAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 44nMpH: 7.5 T: 30°CAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 34nMpH: 7.5 T: 30°CAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
Affinity DataIC50: 74nMpH: 7.5 T: 30°CAssay Description:The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...More data for this Ligand-Target Pair
Affinity DataIC50: 44nMpH: 7.5 T: 30°CAssay Description:The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMpH: 7.5 T: 30°CAssay Description:The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...More data for this Ligand-Target Pair
Affinity DataIC50: 49nMpH: 7.5 T: 30°CAssay Description:The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMpH: 7.5 T: 30°CAssay Description:The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...More data for this Ligand-Target Pair
Affinity DataKd: 1.60nMAssay Description:Binding affinity to human recombinant N-terminal GST-tagged PKGalpha expressed in Baculovirus infected insect Sf9 cells using RKRSRAE as substrate in...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
University of Messina
Curated by ChEMBL
University of Messina
Curated by ChEMBL
Affinity DataKd: 3.90nMAssay Description:Binding affinity to PKAalpha (unknown origin) using Lys-Arg-Thr-Leu-Arg-Arg as substrate after 8 mins in presence of [gamma-32P]ATP by liquid scintil...More data for this Ligand-Target Pair
Affinity DataKd: 1.80nMAssay Description:Binding affinity to PKCbeta2 (unknown origin) using Lys-Arg-Thr-Leu-Arg-Arg as substrate after 8 mins in presence of [gamma-32P]ATP by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of Protein kinase C beta 2More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of Protein kinase C zetaMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C deltaMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of Protein kinase C beta 1More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of Protein kinase C beta 1More data for this Ligand-Target Pair
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of Protein kinase C zetaMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of Protein Kinase C etaMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of human Protein kinase C alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of protein kinase C beta IMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C beta 2More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of protein kinase C alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of Protein kinase C gammaMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of Protein kinase C etaMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C gammaMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C alpha isozymeMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C eta isozymeMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C beta 2 isozymeMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C gamma isozymeMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C delta isozymeMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
University of Messina
Curated by ChEMBL
University of Messina
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibitory concentration of the compound against recombinant human cAMP-dependent Protein kinase AMore data for this Ligand-Target Pair