BDBM340794 4'-(2-(tert-butyl) phenoxy)-3'-(3-(2- fluorophenyl)ureido)-4- methoxy-[1,1'-biphenyl]- 3-carboxylic acid::US9765018, Example 79

SMILES COc1ccc(cc1C(O)=O)-c1ccc(Oc2ccccc2C(C)(C)C)c(NC(=O)Nc2ccccc2F)c1

InChI Key InChIKey=XAJOXNWLUKPUDW-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 340794   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM340794(US9765018, Example 79 | 4'-(2-(tert-butyl) phenoxy...)
Affinity DataIC50: 130nMAssay Description:Inhibition of IDO1 (unknown origin) expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM340794(US9765018, Example 79 | 4'-(2-(tert-butyl) phenoxy...)
Affinity DataIC50: 420nMAssay Description:Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2019
Entry Details
US Patent

TargetCytochrome P450 2C8(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM340794(US9765018, Example 79 | 4'-(2-(tert-butyl) phenoxy...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM340794(US9765018, Example 79 | 4'-(2-(tert-butyl) phenoxy...)
Affinity DataEC50:  5.60E+3nMAssay Description:Transactivation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM340794(US9765018, Example 79 | 4'-(2-(tert-butyl) phenoxy...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed