BDBM368514 N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluoromethyl) isoquinolin-6-amine::US10227343, Example 46
SMILES FC(F)(F)c1nccc2cc(Nc3n[nH]c4ncccc34)ccc12
InChI Key InChIKey=RUEXKBWCUUFJMY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 21 hits for monomerid = 368514
Affinity DataEC50: 67nMAssay Description:The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...More data for this Ligand-Target Pair
Affinity DataEC50: 65nMAssay Description:Positive allosteric modulator activity at human mGlu4 in Chinese hamster CHO cells co-expressing Gqi5 assessed as increase in calcium flux preincubat...More data for this Ligand-Target Pair
Affinity DataEC50: 197nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
Affinity DataEC50: 195nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 ...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 ...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 ...More data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Binding affinity to MAO-B (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Binding affinity to MAO-A (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu8 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu7 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at human mGlu6 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu5 in human HEK cells assessed as increase in calcium flux preincubated for 2.5 mins followed by glu...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu3 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu2 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu1 in human HEK cells assessed assessed as increase in calcium flux preincubated for 2.5 mins follow...More data for this Ligand-Target Pair
Affinity DataEC50: 197nMAssay Description:Positive allosteric modulator activity at rat mGlu4 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2...More data for this Ligand-Target Pair
Affinity DataEC50: 65nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair