BDBM368514 N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluoromethyl) isoquinolin-6-amine::US10227343, Example 46

SMILES FC(F)(F)c1nccc2cc(Nc3n[nH]c4ncccc34)ccc12

InChI Key InChIKey=RUEXKBWCUUFJMY-UHFFFAOYSA-N

Data  6 IC50  15 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 368514   

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50:  67nMAssay Description:The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50:  65nMAssay Description:Positive allosteric modulator activity at human mGlu4 in Chinese hamster CHO cells co-expressing Gqi5 assessed as increase in calcium flux preincubat...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 4(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50:  197nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50:  195nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C19(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C9(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >3.00E+4nMAssay Description:Binding affinity to MAO-B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >3.00E+4nMAssay Description:Binding affinity to MAO-A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 8(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu8 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu7 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 6(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at human mGlu6 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu5 in human HEK cells assessed as increase in calcium flux preincubated for 2.5 mins followed by glu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu3 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 2(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu2 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu1 in human HEK cells assessed assessed as increase in calcium flux preincubated for 2.5 mins follow...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 4(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50:  197nMAssay Description:Positive allosteric modulator activity at rat mGlu4 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50:  65nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed