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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM368514
Substrate
n/a
Meas. Tech.
ChEMBL_2297441
EC50
>30000±n/a nM
Citation
 Panarese, JD; Engers, DW; Wu, YJ; Bronson, JJ; Macor, JE; Chun, A; Rodriguez, AL; Felts, AS; Engers, JL; Loch, MT; Emmitte, KA; Castelhano, AL; Kates, MJ; Nader, MA; Jones, CK; Blobaum, AL; Conn, PJ; Niswender, CM; Hopkins, CR; Lindsley, CW Discovery of VU2957 (Valiglurax): An mGlu ACS Med Chem Lett 10:255-260 (2019) [PubMed] 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
  
Inhibitor
Name:
BDBM368514
Synonyms:
N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluoromethyl) isoquinolin-6-amine | US10227343, Example 46
Type:
Small organic molecule
Emp. Form.:
C16H10F3N5
Mol. Mass.:
329.2793
SMILES:
FC(F)(F)c1nccc2cc(Nc3n[nH]c4ncccc34)ccc12
Structure:
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