BDBM373206 4-(3-((1S,4S)-2,5-diazabicyclo[2.2.2]octan-2- yl)-1-cyclopropyl-7-fluoro-1H-pyrazolo[4,3- c]pyridin-6-yl)-5-ethynyl-6-fluoronaphthalen-2- ol::US20260022118, Example 106

SMILES C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5C[C@@H]6CC[C@H]5CN6)nn(C5CC5)c4c3F)c12

InChI Key InChIKey=KHIXLLWESRIMRA-UHFFFAOYSA-N

Data  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373206   

TargetGTPase NRas [G12D](Human)
University of Texas System

US Patent
LigandChemical structure of BindingDB Monomer ID 373206BDBM373206(4-(3-((1S,4S)-2,5-diazabicyclo[2.2.2]octan-2- yl)-...)
Affinity DataKd:  9.39nMAssay Description:The assay was run at 25° C. with a data collection rate of 10 Hz. All samples were flowed over both a reference surface and an active surface. Sample...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent