BDBM378654 N-{1-[(1-benzyl-1H-pyrazol-4-yl)methyl]azetidin-3-yl}-1-cyclopropyl-1H-1,2,3-triazole-4-carboxamide::US10266526, Compound 792

SMILES O=C(NC1CN(Cc2cnn(Cc3ccccc3)c2)C1)c1cn(nn1)C1CC1

InChI Key InChIKey=SGVKMHGESLELKH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 378654   

TargetN-lysine methyltransferase SMYD2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 16nMAssay Description:Inhibition of FLAG and C-terminally Avi-tagged full length SMYD2 (unknown origin) expressed in Sf9 cells using SAM and histone H3 (1 to 29 residues) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 16nMAssay Description:Inhibition of SMYD2 (unknown origin) using N-terminal GST-tagged MAP3K2 and 3H-SAM as substrate for 2 hrs by TopCount NXT plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 16.4nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetN-lysine methyltransferase SMYD2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human SMYD2 overexpressing human KYSE-150 cells assessed as SMYD2 assessed as reduction in BTF3 monomethylation by Western blot analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 31nMAssay Description:Inhibition of SMYD2 in human HEK293T cells assessed as BTF3me1 levels by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETD7(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SETD7 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT1(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EHMT1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SETD2 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SUV39H1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EHMT2 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EZH2 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of WHSC1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EZH1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NSD1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRDM9 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT6 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT3 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT7 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT8 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed