BDBM378654 N-{1-[(1-benzyl-1H-pyrazol-4-yl)methyl]azetidin-3-yl}-1-cyclopropyl-1H-1,2,3-triazole-4-carboxamide::US10266526, Compound 792

SMILES O=C(NC1CN(Cc2cnn(Cc3ccccc3)c2)C1)c1cn(nn1)C1CC1

InChI Key InChIKey=SGVKMHGESLELKH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 378654   

TargetN-lysine methyltransferase SMYD2(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM378654(N-{1-[(1-benzyl-1H-pyrazol-4-yl)methyl]azetidin-3-...)
Affinity DataIC50:  16.4nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetN-lysine methyltransferase SMYD2(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM378654(N-{1-[(1-benzyl-1H-pyrazol-4-yl)methyl]azetidin-3-...)
Affinity DataIC50:  31nMAssay Description:Inhibition of human SMYD2 overexpressing human KYSE-150 cells assessed as SMYD2 assessed as reduction in BTF3 monomethylation by Western blot analysi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetN-lysine methyltransferase SMYD2(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM378654(N-{1-[(1-benzyl-1H-pyrazol-4-yl)methyl]azetidin-3-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of FLAG and C-terminally Avi-tagged full length SMYD2 (unknown origin) expressed in Sf9 cells using SAM and histone H3 (1 to 29 residues) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed