BDBM381391 4-chloro-N-(4-isopropylphenyl)-1- (tetrahydro-2H-thiopyran-4-yl)-1H- pyrazolo[3,4-b]pyridine-5- carboxamide::US10272074, Example 224

SMILES CC(C)c1ccc(NC(=O)c2cnc3n(ncc3c2Cl)C2CCSCC2)cc1

InChI Key InChIKey=XNRBGHWMAUNLJQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 381391   

TargetGlucocorticoid receptor(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM381391(4-chloro-N-(4-isopropylphenyl)-1- (tetrahydro-2H-t...)
Affinity DataIC50: 50nMAssay Description:The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent