BDBM383178 US10278962, Compound 13

SMILES CC(O)(COC(=O)c1ccc(C#N)cc1)[C@@H]1C[C@H](OC(=O)c2ccc(C#N)cc2)[C@@]2(C)Oc3cc(-c4cccnc4)oc(=O)c3C(=O)[C@@H]2C1

InChI Key InChIKey=WEOCJMZXRUXKAV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 383178   

TargetSterol O-acyltransferase 2(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 383178BDBM383178(US10278962, Compound 13)
Affinity DataIC50: 12nMAssay Description:1. Purpose:The analogues of Pyripyropene A structure were tested for their inhibitory effect on ACAT2 activity at intact cellular level by a method i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
US Patent

TargetSterol O-acyltransferase 2(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 383178BDBM383178(US10278962, Compound 13)
Affinity DataIC50: 23nMAssay Description:1. Purpose:The analogues of Pyripyropene A structure were tested for their inhibitory effect on ACAT2 activity at intact cellular level by a method i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
US Patent

TargetSterol O-acyltransferase 1(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 383178BDBM383178(US10278962, Compound 13)
Affinity DataIC50: 1.78E+4nMAssay Description:1. Purpose:The analogues of Pyripyropene A structure were tested for their inhibitory effect on ACAT2 activity at intact cellular level by a method i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
US Patent