BDBM445964 US10669246, Example 17::US10968188, Example 17

SMILES CC(=C)c1ccc(C)c(c1)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1

InChI Key InChIKey=PRKSRBXBOUMMKD-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 445964   

TargetTyrosine-protein kinase ABL1(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM445964(US10669246, Example 17 | US10968188, Example 17)
Affinity DataIC50: 7.80nMAssay Description:ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM445964(US10669246, Example 17 | US10968188, Example 17)
Affinity DataIC50: 7.80nMAssay Description:c-abl kinase activity was measured by Promega's ADP-Glo Assay. In this assay, His-tagged recombinant human ABL1 (0.25 ng/μl) is incubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM445964(US10669246, Example 17 | US10968188, Example 17)
Affinity DataIC50: 7.80nMAssay Description:ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM445964(US10669246, Example 17 | US10968188, Example 17)
Affinity DataIC50: 7.80nMAssay Description:c-abl kinase activity was measured by Promega's ADP-Glo Assay. In this assay, His-tagged recombinant human ABL1 (0.25 ng/μl) is incubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM445964(US10669246, Example 17 | US10968188, Example 17)
Affinity DataIC50: 1.30E+3nMAssay Description:ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Bovine serum albumin (BSA) and dimethylsulfoxide (DMSO) were purchased from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM445964(US10669246, Example 17 | US10968188, Example 17)
Affinity DataIC50: 1.30E+3nMAssay Description:PDGFRα kinase activity was measured by Promega's ADP-Glo Assay. In this assay, Recombinant human PDGFRα (40 ng) is incubated with 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM445964(US10669246, Example 17 | US10968188, Example 17)
Affinity DataIC50: 1.00E+4nMAssay Description:ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), Manganese(II) chloride (MnCl2), Bovine serum albumin (BSA) and dimethylsulf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM445964(US10669246, Example 17 | US10968188, Example 17)
Affinity DataKi: >1.00E+4nMAssay Description:c-Kit kinase activity was measured by Promega's ADP-Glo Assay. In this assay, Recombinant human c-Kit (100 ng) is incubated with 5 μL of com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent