BDBM490277 US10968215, Compound 154
SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(ccn2c(C(C)N2CCN(CC(F)(F)F)CC2)c1C)-c1ccn[nH]1
InChI Key
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 490277
TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical
US Patent
Shanghai Haihe Pharmaceutical
US Patent
Affinity DataIC50: <100nMAssay Description:EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital Of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: <100nMAssay Description:Inhibition of wild-type EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital Of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: <100nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital Of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: <100nMAssay Description:EZH2 wild type: Experimental method: avdin of a final concentration of 100 nM was used to coat 96-well plate at 10 μL/well, placed in a wet box ...More data for this Ligand-Target Pair