BDBM491945 (S)—N-(2-Hydroxy-2-methylpropyl)-4-(2-methylpiperidine-1-carbonyl)-5-(6-(neopentylamino)-4-(trifluoromethyl)pyridin-3-yl)thiazole-2-carboxamide::US10975068, Example 86

SMILES C[C@H]1CCCCN1C(=O)c1nc(sc1-c1cnc(NCC(C)(C)C)cc1C(F)(F)F)C(=O)NCC(C)(C)O

InChI Key InChIKey=QMFUYPDEWUXDIT-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 491945   

TargetNuclear receptor ROR-gamma(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM491945(US10975068, Example 86 | (S)—N-(2-Hydroxy-2-m...)
Affinity DataKd:  0.170nMAssay Description:Inhibition of human RORgammmat LBD expressed in Escherichia coli by ThermoFluro assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM491945(US10975068, Example 86 | (S)—N-(2-Hydroxy-2-m...)
Affinity DataKd:  0.170nMAssay Description:1,8-ANS (Invitrogen) was used as a fluorescent dye. Protein and compound solutions are dispensed into black 384-well polypropylene PCR microplates (A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent