BDBM491953 (S)-4-(4,4-Difluoro-2-methylpyrrolidine-1-carbonyl)-5-(4-(difluoromethyl)-6-(tert-pentylamino)pyridin-3-yl)-N-(2-hydroxy-2-methylpropyl)thiazole-2-carboxamide::US10975068, Example 94

SMILES CCC(C)(C)Nc1cc(C(F)F)c(cn1)-c1sc(nc1C(=O)N1CC(F)(F)C[C@@H]1C)C(=O)NCC(C)(C)O

InChI Key InChIKey=IJUGKPFCMFVUQM-UHFFFAOYSA-N

Data  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 491953   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM491953(US10975068, Example 94 | (S)-4-(4,4-Difluoro-2-met...)
Affinity DataKd:  0.360nMAssay Description:1,8-ANS (Invitrogen) was used as a fluorescent dye. Protein and compound solutions are dispensed into black 384-well polypropylene PCR microplates (A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent