BDBM491991 (S)—N-(2-Hydroxy-2-methylpropyl)-4-(2-methylpyrrolidine-1-carbonyl)-5-(6-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)-4-(trifluoromethyl)pyridin-3-yl)thiazole-2-carboxamide::US10975068, Example 132

SMILES C[C@H]1CCCN1C(=O)c1nc(sc1-c1cnc(NC(C)(C)C(F)(F)F)cc1C(F)(F)F)C(=O)NCC(C)(C)O

InChI Key InChIKey=XODCEXRSLOWHKZ-UHFFFAOYSA-N

Data  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 491991   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM491991(US10975068, Example 132 | (S)—N-(2-Hydroxy-2-...)
Affinity DataKd:  0.410nMAssay Description:1,8-ANS (Invitrogen) was used as a fluorescent dye. Protein and compound solutions are dispensed into black 384-well polypropylene PCR microplates (A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent