BDBM492045 4-((S)-4,4-Difluoro-2-methylpyrrolidine-1-carbonyl)-N-((3R,4S)-4-hydroxytetrahydrofuran-3-yl)-5-(6-(((1-methylcyclobutyl)amino)-4-(trifluoromethyl)pyridine-3-yl)thiazole-2-carboxamide::US10975068, Example 186

SMILES C[C@H]1CC(F)(F)CN1C(=O)c1nc(sc1-c1cnc(NC2(C)CCC2)cc1C(F)(F)F)C(=O)N[C@H]1COC[C@@H]1O

InChI Key InChIKey=OQMNYHOSLVWKOM-UHFFFAOYSA-N

Data  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 492045   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM492045(US10975068, Example 186 | 4-((S)-4,4-Difluoro-2-me...)
Affinity DataKd:  0.180nMAssay Description:1,8-ANS (Invitrogen) was used as a fluorescent dye. Protein and compound solutions are dispensed into black 384-well polypropylene PCR microplates (A...More data for this Ligand-Target Pair
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Date in BDB:
10/20/2021
Entry Details
US Patent