BDBM492285 4-[(2S)-4,4-Difluoro-2-methyl-pyrrolidine-1-carbonyl]-5-[4-(difluoromethyl)-6-[[(1S)-1-(trifluoromethyl)propyl]amino]-3-pyridyl]-N-(1,1-dioxothian-4-yl)thiazole-2-carboxamide::US10975068, Example 426

SMILES CC[C@H](Nc1cc(C(F)F)c(cn1)-c1sc(nc1C(=O)N1CC(F)(F)C[C@@H]1C)C(=O)NC1CCS(=O)(=O)CC1)C(F)(F)F

InChI Key InChIKey=CPQZJTFMSIMBMY-UHFFFAOYSA-N

Data  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 492285   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM492285(4-[(2S)-4,4-Difluoro-2-methyl-pyrrolidine-1-carbon...)
Affinity DataKd:  0.370nMAssay Description:1,8-ANS (Invitrogen) was used as a fluorescent dye. Protein and compound solutions are dispensed into black 384-well polypropylene PCR microplates (A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent