BDBM492298 4-((1s,4s)-7-Azabicyclo[2.2.1]heptane-7-carbonyl)-5-[6-[[(1S)-1-cyclopropyl-2,2,2-trifluoro-ethyl]amino]-4-(difluoromethyl)-3-pyridyl]-N-[(1R,2R)-2-hydroxycyclopentyl]thiazole-2-carboxamide::US10975068, Example 439

SMILES O[C@@H]1CCC[C@H]1NC(=O)c1nc(C(=O)N2C3CCC2CC3)c(s1)-c1cnc(N[C@@H](C2CC2)C(F)(F)F)cc1C(F)F

InChI Key InChIKey=NOWVUFUSESSRAI-UHFFFAOYSA-N

Data  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 492298   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM492298(4-((1s,4s)-7-Azabicyclo[2.2.1]heptane-7-carbonyl)-...)
Affinity DataKd:  0.270nMAssay Description:1,8-ANS (Invitrogen) was used as a fluorescent dye. Protein and compound solutions are dispensed into black 384-well polypropylene PCR microplates (A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent