BDBM50021626 CHEMBL3298400

SMILES CC(C)(C)CNC(=O)CC1CNC(=O)c2cc(cn12)-c1ccsc1

InChI Key InChIKey=PNMQDIXULZYDDT-UHFFFAOYSA-N

Data  52 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 52 hits for monomerid = 50021626   

TargetFocal adhesion kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEphrin type-A receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EphA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlycogen synthase kinase-3 beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase haspin(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of haspin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity immunoglobulin gamma Fc receptor I(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInsulin receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMast/stem cell growth factor receptor Kit(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of KIT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Lck(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Lyn(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-activated protein kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPKAPK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMaternal embryonic leucine zipper kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MELK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of c-MET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target40S ribosomal protein S27(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase 26(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MST4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Nek6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of NEK6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase NIM1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of NIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of P38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase PAK 4(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PERK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProtein kinase C beta type(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKC-beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase SYK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Syk (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity nerve growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity nerve growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TLK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of human PIM1 using ARK-RERTYSFGHHA as substrate incubated for 60 mins prior to substrate addition by topcount scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein kinase ABL1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Bcr-ABL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetActivated CDC42 kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ACK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetALK tyrosine kinase receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of aurora kinase 1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of aurora kinase 2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BUB1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ZAP-70(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProtein-tyrosine kinase 6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BRK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDC7/DBF4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEukaryotic elongation factor 2 kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EEF2K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021626(CHEMBL3298400)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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