BDBM50022859 CHEMBL407670::Pro-His-Pro-Phe-His-Leu[CH2NH]Val-Ile-His-Lys::Pro-His-Prp-Phe-His-Leu(psi)[CH2NH]Val-Ile-His-Lys::Pro-His-Prp-Phe-His-Leu(psi)[CH2NH]Val-Ile-His-Lys(H-142)

SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCCN)C(O)=O

InChI Key InChIKey=XIZSMQBWVQNHCA-NIRMQQKASA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50022859   

TargetRenin(Human)
Upjohn

Curated by ChEMBL
LigandPNGBDBM50022859(CHEMBL407670 | Pro-His-Pro-Phe-His-Leu[CH2NH]Val-I...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRenin(Human)
Upjohn

Curated by ChEMBL
LigandPNGBDBM50022859(CHEMBL407670 | Pro-His-Pro-Phe-His-Leu[CH2NH]Val-I...)
Affinity DataKd:  8nMAssay Description:Dissociation constant (Kd) of renin inhibitor was determined over a temperature range of 8-37 degree by the fluorescence displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRenin(Human)
Upjohn

Curated by ChEMBL
LigandPNGBDBM50022859(CHEMBL407670 | Pro-His-Pro-Phe-His-Leu[CH2NH]Val-I...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition of purified Human kidney renin (250 pg/mL) incubated with angiotensinogen at pH 7.2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRenin(Human)
Upjohn

Curated by ChEMBL
LigandPNGBDBM50022859(CHEMBL407670 | Pro-His-Pro-Phe-His-Leu[CH2NH]Val-I...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed