BDBM50032732 CHEMBL3354708

SMILES COc1cncc(-c2ccc3c(c2)[C@@]2(COC(N)=N2)c2cc(OCC(C)(C)C)ccc2O3)c1

InChI Key InChIKey=ZTVRKPQAQQUAMM-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50032732   

TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50032732BDBM50032732(CHEMBL3354708)
Affinity DataIC50: 4nMAssay Description:Inhibition of BACE1 (unknown origin) assessed as enhancement of fluorescence intensityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50032732BDBM50032732(CHEMBL3354708)
Affinity DataIC50: 80nMAssay Description:Inhibition of BACE1 in HEK293T cells expressing APPswedish mutant assessed as inhibition of amyloid beta 40 production by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50032732BDBM50032732(CHEMBL3354708)
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of human ERG expressing HEK293 cells by [3H]dofetilide binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed