BDBM50048365 CHEMBL3309998

SMILES Nc1nc2c3ccc(NCCO)cc3nc(Cc3ccc4OCOc4c3)n2n1

InChI Key InChIKey=QPVNTDBWWRFMIC-UHFFFAOYSA-N

Data  1 KI  51 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 52 hits for monomerid = 50048365   

TargetHeat shock protein HSP 90-beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataKi:  12nMAssay Description:Inhibition of Hsp90 (unknown origin) by FP displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetInsulin receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Lyn(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-activated protein kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPKAPK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMaternal embryonic leucine zipper kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MELK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of c-MET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target40S ribosomal protein S27(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase 26(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MST4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetActivated CDC42 kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ACK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetALK tyrosine kinase receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Aurora 1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Nek6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of NEK6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase NIM1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of NIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of P38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase PAK 4(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlatelet-derived growth factor receptor beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PERK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKAalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProtein kinase C beta type(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKCbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase SYK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Syk (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity nerve growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase tousled-like 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TLK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ZAP-70(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock cognate 71 kDa protein(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HSC70 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Aurora 2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BUB1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProtein-tyrosine kinase 6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BRK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEukaryotic elongation factor 2 kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EEF2K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEphrin type-A receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EphA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetFocal adhesion kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetFibroblast growth factor receptor 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlycogen synthase kinase-3 beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase haspin(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Haspin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity immunoglobulin gamma Fc receptor I(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50048365(CHEMBL3309998)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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