BDBM50068270 (E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one::(E)-3-[5-(1,1-Dimethyl-allyl)-4-hydroxy-2-methoxy-phenyl]-1-(4-hydroxy-phenyl)-propenone::3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one::3-[5-((E)-1,1-Dimethyl-allyl)-4-hydroxy-2-methoxy-phenyl]-1-(4-hydroxy-phenyl)-propenone::CHEMBL139702::Licochalcone A

SMILES COc1cc(O)c(cc1\C=C\C(=O)c1ccc(O)cc1)C(C)(C)C=C

InChI Key InChIKey=KAZSKMJFUPEHHW-UHFFFAOYSA-N

Data  46 IC50  3 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 55 hits for monomerid = 50068270   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 6.20nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 7.10nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 7.80nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 19nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 42nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on topotecan-induced cytotoxicity by measuring topoteca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 44nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on topotecan-induced cytotoxicity by measuring topoteca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 51nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on topotecan-induced cytotoxicity by measuring topoteca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 70nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on mitoxantrone-induced cytotoxicity by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 75nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on mitoxantrone-induced cytotoxicity by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 86nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on mitoxantrone-induced cytotoxicity by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 90nMAssay Description:Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on topotecan-induced cytotoxicity by measuring topoteca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 130nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on topotecan-induced cytotoxicity by mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 144nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on topotecan-induced cytotoxicity by mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 148nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on topotecan-induced cytotoxicity by mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 310nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 367nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on topotecan-induced cytotoxicity by mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 410nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 442nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on mitoxantrone-induced cytotoxicity by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 610nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 970nMAssay Description:Induction of UGT1A1 (unknown origin) assessed as increase in intracellular acidic autophagy vesicles formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 1.03E+3nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 1.53E+3nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 2.63E+3nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Guizhou Medcial University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataKd:  2.81E+3nMAssay Description:Binding affinity to IDH1 R132C mutant (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Guizhou Medcial University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 5.17E+3nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Guizhou Medcial University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 5.18E+3nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 6.80E+3nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus)
Chosun University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 1.24E+4nMAssay Description:Inhibition of oseltamivir-resistant H1N1 swine influenza virus neuraminidase H274Y mutant activity expressed in HEK293T cells after 2 hrs by spectrof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Guizhou Medcial University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataKd:  1.28E+4nMAssay Description:Binding affinity to IDH1 R132H mutant (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataEC50:  1.40E+4nMAssay Description:Modulation of ABCG2 (unknown origin) expressed in High Five insect cell vesicle membrane assessed as stimulation of ATPase activity after 20 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus)
Chosun University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 1.59E+4nMAssay Description:Inhibition of wild type H1N1 swine influenza virus neuraminidase activity expressed in HEK293T cells after 2 hrs by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Chonnam National University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Chonnam National University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of recombinant human PTP1B using pNPP as substrate measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Chonnam National University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of recombinant human PTP1B assessed as hydrolysis of p-nitrophenyl phosphate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetSialidase(Clostridium perfringens)
Chosun University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 2.03E+4nMAssay Description:Inhibition of Clostridium perfringens neuraminidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
First Affinity Hospital of Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 2.23E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetDipeptidyl peptidase 4(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 3.04E+4nMAssay Description:Inhibition of DPP4 in human plasma using GP-BAN as fluorescent substrate preincubated for 5 mins followed by substrate addition and measured for 20 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 3.95E+4nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 4.93E+4nMAssay Description:Reversal of human ABCC1-mediated multidrug resistance in HEK293/MRP1 cells assessed as effect on etoposide-induced cytotoxicity by measuring etoposid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Guizhou Medcial University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataKd: >5.00E+4nMAssay Description:Binding affinity to IDH1 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus)
Chosun University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 5.31E+4nMAssay Description:Inhibition of Influenza A H9N2 virus neuraminidase activity after 2 hrs by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus)
Chosun University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 5.31E+4nMAssay Description:Noncompetitive inhibition of Influenza A H1N1 virus neuraminidase activity by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 5.36E+4nMAssay Description:Reversal of human ABCC1-mediated multidrug resistance in HEK293/MRP1 cells assessed as effect on etoposide-induced cytotoxicity by measuring etoposid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus)
Chosun University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 5.61E+4nMAssay Description:Inhibition of Influenza A H1N1 virus neuraminidase activity after 2 hrs by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 5.65E+4nMAssay Description:Reversal of human ABCC1-mediated multidrug resistance in HEK293/MRP1 cells assessed as effect on etoposide-induced cytotoxicity by measuring etoposid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 6.67E+4nMAssay Description:Reversal of human ABCC1-mediated multidrug resistance in HEK293/MRP1 cells assessed as effect on etoposide-induced cytotoxicity by measuring etoposid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Guizhou Medcial University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 7.69E+4nMAssay Description:Inhibition of human IDH1 R132H mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Guizhou Medcial University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataKi:  7.69E+4nMAssay Description:Binding affinity to human recombinant IDH1 R132H mutant expressed in Escherichia coli BL21 (DE3) cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Guizhou Medcial University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 7.69E+4nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Taipei Chang Gung Memorial Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 9.49E+4nMAssay Description:Reversal of human ABCB1-mediated multidrug resistance in HEK293/MDR19 cells assessed as effect on colchicine-induced cytotoxicity at 0.5 uM by measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
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