BDBM50104622 CHEMBL3593550

SMILES Oc1ccc(C[C@@H]2CNC(=O)C(=O)N2C[C@@H]2CCCN2C[C@@H](Cc2ccc3ccccc3c2)N2C[C@H](Cc3ccc(O)cc3)N(CCC34CC5CC(CC(C5)C3)C4)C(=O)C2=O)cc1

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50104622   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104622(CHEMBL3593550)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of ADAM17 in human A549 cells assessed as potentiation of gefitinib-mediated inhibition of cell viability by measuring gefitinib IC50 at 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104622(CHEMBL3593550)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of ADAM17 (unknown origin) preincubated for 30 mins followed by substrate addition measured every 30 mins for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104622(CHEMBL3593550)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of ADAM17 in human THP1 cells assessed as inhibition of LPS-stimulated TNFalpha cleavage after 1 hr by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104622(CHEMBL3593550)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP14 (unknown origin) using Mca-KLPGL-Dnp-AR as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104622(CHEMBL3593550)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of ADAM10 (unknown origin) preincubated for 30 mins followed by substrate addition measured every 30 mins for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104622(CHEMBL3593550)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP8 (unknown origin) using Mca-KLPGL-Dnp-AR as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed