BDBM50184861 CHEMBL205089::N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}-urea

SMILES COc1cc2ncnc(Oc3ccc(NC(=O)NC4CCCCC4)cc3)c2cc1OC

InChI Key InChIKey=ROYLPDZGPLFQSV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50184861   

TargetMast/stem cell growth factor receptor Kit(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184861(CHEMBL205089 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)
Affinity DataIC50:  27nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184861(CHEMBL205089 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)
Affinity DataIC50:  7nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50184861(CHEMBL205089 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50184861(CHEMBL205089 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant human VEGFR-2-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50184861(CHEMBL205089 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50184861(CHEMBL205089 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human EGFR-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed