BDBM50215763 1-methyl-3-(5-((1-methyl-4-((4-(trifluoromethylthio)phenyl)carbamoyl)-1H-pyrazol-5-ylamino)methyl)pyridin-2-yl)urea::CHEMBL247797

SMILES CNC(=O)Nc1ccc(CNc2c(cnn2C)C(=O)Nc2ccc(SC(F)(F)F)cc2)cn1

InChI Key InChIKey=MHVFDATVTOZXQW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50215763   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215763(1-methyl-3-(5-((1-methyl-4-((4-(trifluoromethylthi...)
Affinity DataIC50: 15nMAssay Description:Inhibition of pAktMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215763(1-methyl-3-(5-((1-methyl-4-((4-(trifluoromethylthi...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215763(1-methyl-3-(5-((1-methyl-4-((4-(trifluoromethylthi...)
Affinity DataIC50: 62nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215763(1-methyl-3-(5-((1-methyl-4-((4-(trifluoromethylthi...)
Affinity DataIC50: 154nMAssay Description:Inhibition of b-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215763(1-methyl-3-(5-((1-methyl-4-((4-(trifluoromethylthi...)
Affinity DataIC50: 899nMAssay Description:Inhibition of P-ERKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed