BDBM50246926 CHEMBL4062204::US10570121, Example 82

SMILES COc1cc(C)[nH]c(=O)c1CN1CCc2c(Cl)cc([C@@H](OC)C3COC3)c(Cl)c2C1=O

InChI Key InChIKey=RXCVUHMIWHRLDF-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50246926   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 50246926BDBM50246926(CHEMBL4062204 | US10570121, Example 82)
Affinity DataKi:  6nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 50246926BDBM50246926(CHEMBL4062204 | US10570121, Example 82)
Affinity DataIC50: 75nMAssay Description:Inhibition of EZH2 in human KARPAS422 cells assessed as reduction in H3K27me3 level after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246926BDBM50246926(CHEMBL4062204 | US10570121, Example 82)
Affinity DataIC50: 131nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent