BDBM50246926 CHEMBL4062204::US10570121, Example 82

SMILES CO[C@@H](C1COC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key InChIKey=RXCVUHMIWHRLDF-FQEVSTJZSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50246926   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50246926(CHEMBL4062204 | US10570121, Example 82)
Affinity DataKi:  6nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2 [2-746,Y641N](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50246926(CHEMBL4062204 | US10570121, Example 82)
Affinity DataIC50:  131nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50246926(CHEMBL4062204 | US10570121, Example 82)
Affinity DataIC50:  75nMAssay Description:Inhibition of EZH2 in human KARPAS422 cells assessed as reduction in H3K27me3 level after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed