BDBM50246964 CHEMBL4060640::US10570121, Example 18

SMILES Cc1cc(C)c(CN2CCc3c(Cl)cc([C@H](C)CO)c(Cl)c3C2=O)c(=O)[nH]1

InChI Key InChIKey=GMVWARWJGLYCAS-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50246964   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 50246964BDBM50246964(CHEMBL4060640 | US10570121, Example 18)
Affinity DataKi:  115nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 50246964BDBM50246964(CHEMBL4060640 | US10570121, Example 18)
Affinity DataIC50: 126nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 50246964BDBM50246964(CHEMBL4060640 | US10570121, Example 18)
Affinity DataIC50: 129nMAssay Description:Inhibition of EZH2 in human KARPAS422 cells assessed as reduction in H3K27me3 level after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246964BDBM50246964(CHEMBL4060640 | US10570121, Example 18)
Affinity DataIC50: 995nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent