BDBM50270425 CHEMBL4080062
SMILES OCc1cc(Oc2ccc3c(cccc3c2)C(=O)Nc2cccc(c2)C(F)(F)F)ncn1
InChI Key InChIKey=JNLSTLQFDDAULK-UHFFFAOYSA-N
Data 16 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50270425
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of KDR (unknown origin) expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >500nMAssay Description:Inhibition of BCR-ABL (unknown origin) autophosphorylation expressed in mouse 32D cells by ELISA-based assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant GST-fused VEGFR1 kinase domain transphosphorylation expressed in baculovirus expression system using poly-Glu-Tyr (4:...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Mouse)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of mouse recombinant GST-fused VEGFR2 kinase domain expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measu...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of VEGF-induced human VEGFR2 autophosphorylation transfected in CHO cells measured after 2 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human recombinant GST-fused VEGFR2 kinase domain transphosphorylation expressed in baculovirus expression system using poly-Glu-Tyr (4:...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of human recombinant GST-fused c-KIT expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measured after 10 mi...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of RET (unknown origin) autophosphorylation expressed in mouse NIH3T3 cells by ELISA-based assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of VEGF-induced human VEGFR2 autophosphorylation expressed in HUVEC cells measured after 2 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of PDGFR (unknown origin) autophosphorylation expressed in mouse BALB/3T3 clone A31 cells by ELISA-based assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of KIT K642E mutant (unknown origin) autophosphorylation expressed in human GIST882 cells by ELISA-based assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >500nMAssay Description:Inhibition of EGFR (unknown origin) autophosphorylation expressed in human A-431 cells by ELISA-based assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >500nMAssay Description:Inhibition of ERBB2 (unknown origin) autophosphorylation expressed in human BT-474 cells by ELISA-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Inhibition of INSR (unknown origin) autophosphorylation expressed in human A14 cells by ELISA-based assayMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >500nMAssay Description:Inhibition of IGF1R (unknown origin) autophosphorylation expressed in human NWT-21 cells by ELISA-based assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant GST-fused VEGFR3 kinase domain transphosphorylation expressed in baculovirus expression system using poly-Glu-Tyr (4:...More data for this Ligand-Target Pair