BDBM50380620 CHEMBL2016866

SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCC(=O)NCc3cccc(CNC(=O)CC[C@@H](NS(=O)(=O)Cc4ccccc4)C(=O)N2)c3)cc1

InChI Key InChIKey=DBLYNSSCIKMVDW-UHFFFAOYSA-N

Data  9 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50380620   

TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50380620(CHEMBL2016866)
Affinity DataKi:  5.10nMAssay Description:Inhibition of activated protein C by dixon plot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM50380620(CHEMBL2016866)
Affinity DataKi:  25nMpH: 8.0Assay Description:The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent

TargetPlasma kallikrein(Human)
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM50380620(CHEMBL2016866)
Affinity DataKi:  25.4nMAssay Description:Inhibition of plasma kallikrein by dixon plot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPlasminogen(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50380620(CHEMBL2016866)
Affinity DataKi:  431nMAssay Description:Inhibition of plasmin by dixon plot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPlasminogen(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50380620(CHEMBL2016866)
Affinity DataKi:  431nMpH: 8.0Assay Description:The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent

TargetProthrombin(Human)
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM50380620(CHEMBL2016866)
Affinity DataKi:  2.02E+3nMpH: 8.0Assay Description:The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent

TargetProthrombin(Human)
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM50380620(CHEMBL2016866)
Affinity DataKi:  2.02E+3nMAssay Description:Inhibition of thrombin by dixon plot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50380620(CHEMBL2016866)
Affinity DataKi:  3.43E+3nMAssay Description:Inhibition of factor 10a by dixon plot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50380620(CHEMBL2016866)
Affinity DataKi:  3.43E+3nMpH: 8.0Assay Description:The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent