BDBM50453185 CHEMBL4203825

SMILES CCN1CCN(c2ccc(Nc3nc(N[C@H]4CC[C@H](N)CC4)nc4c3ncn4C3CCCC3)cc2)CC1

InChI Key InChIKey=AGAQJVYMHPGORF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50453185   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Palack£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50453185BDBM50453185(CHEMBL4203825)
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) D835Y mutant expressed in Sf9 insect cells using poly (Ala,Glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Palack£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50453185BDBM50453185(CHEMBL4203825)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Palack£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50453185BDBM50453185(CHEMBL4203825)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant wild type human FLT3 (R571 to S993 residues) expressed in Sf9 insect cells using poly (Ala,Glu,Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed