BDBM50468106 CHEMBL4280801::US11247985, Table 3.49

SMILES CN1CCN(C2(CNC3CCN(c4cccc(-c5cc6cc(F)ccc6[nH]5)c4)CC3)CCC2)CC1

InChI Key InChIKey=IKTPSOBWZZCXTI-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50468106   

TargetSmall VCP/p97-interacting protein(Human)
University Of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50468106BDBM50468106(CHEMBL4280801 | US11247985, Table 3.49 | US1255948...)
Affinity DataIC50: 15nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2026
Entry Details US Patent

TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50468106BDBM50468106(CHEMBL4280801 | US11247985, Table 3.49 | US1255948...)
Affinity DataIC50: 15nMAssay Description:To optimize p97 inhibitors, the C-5 trifluoromethylated trifluoromethylated indole 12 was generated as a promising lead structure. In the ADP-Glo ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50468106BDBM50468106(CHEMBL4280801 | US11247985, Table 3.49 | US1255948...)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant full length human p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2 (DE3) using 100 uM ATP as substrate after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50468106BDBM50468106(CHEMBL4280801 | US11247985, Table 3.49 | US1255948...)
Affinity DataEC50:  1.50E+4nMAssay Description:Inhibition of human p97 in human HeLa cells harboring UbG76V-GFP assessed as accumulation of UbG76V after 1 hr by microscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50468106BDBM50468106(CHEMBL4280801 | US11247985, Table 3.49 | US1255948...)
Affinity DataEC50: >4.00E+4nMAssay Description:Inhibition of human p97 in human HeLa cells harboring UbG76V-GFP assessed as accumulation of UbG76V after 6 hrs by microscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed