BDBM50468106 CHEMBL4280801::US11247985, Table 3.49
SMILES CN1CCN(CC1)C1(CNC2CCN(CC2)c2cccc(c2)-c2cc3cc(F)ccc3[nH]2)CCC1
InChI Key InChIKey=IKTPSOBWZZCXTI-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50468106
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh Chemical Diversity Center
Curated by ChEMBL
University Of Pittsburgh Chemical Diversity Center
Curated by ChEMBL
Affinity DataEC50: >4.00E+4nMAssay Description:Inhibition of human p97 in human HeLa cells harboring UbG76V-GFP assessed as accumulation of UbG76V after 6 hrs by microscopic analysisMore data for this Ligand-Target Pair
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh Chemical Diversity Center
Curated by ChEMBL
University Of Pittsburgh Chemical Diversity Center
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:To optimize p97 inhibitors, the C-5 trifluoromethylated trifluoromethylated indole 12 was generated as a promising lead structure. In the ADP-Glo ass...More data for this Ligand-Target Pair
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh Chemical Diversity Center
Curated by ChEMBL
University Of Pittsburgh Chemical Diversity Center
Curated by ChEMBL
Affinity DataEC50: 1.50E+4nMAssay Description:Inhibition of human p97 in human HeLa cells harboring UbG76V-GFP assessed as accumulation of UbG76V after 1 hr by microscopic analysisMore data for this Ligand-Target Pair
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh Chemical Diversity Center
Curated by ChEMBL
University Of Pittsburgh Chemical Diversity Center
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant full length human p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2 (DE3) using 100 uM ATP as substrate after...More data for this Ligand-Target Pair