BDBM50496837 CHEMBL3218641

SMILES CCCC[C@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)C[C@@H](CCc2ccccc2)NC(=O)[C@@H]2CCCCN2C(=O)C(=O)C(C)(C)COC1=O

InChI Key InChIKey=XETOSBIRHFZUTI-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50496837   

TargetGTPase KRas(Human)
The Ohio State University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50496837BDBM50496837(CHEMBL3218641)
Affinity DataIC50: 700nMAssay Description:Inhibition of recombinant HA-tagged K-Ras G12V mutant (unknown origin) assessed as disruption of interaction with GST-tagged Raf-RBD after overnight ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetGTPase KRas(Human)
The Ohio State University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50496837BDBM50496837(CHEMBL3218641)
Affinity DataKd:  830nMAssay Description:Binding affinity to K-Ras G12V mutant (unknown origin) after 2 hrs by fluorescence polarization-based spectrofluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed