BDBM50514164 CHEMBL4437065

SMILES Cc1cc(C)c(cc1C)-c1cc(NC(=O)CSc2nnc3c(n2)[nH]c2ccccc32)n(n1)-c1ccccc1

InChI Key InChIKey=NOTFJSIATRPNAH-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50514164   

TargetATP-dependent translocase ABCB1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50514164(CHEMBL4437065)
Affinity DataIC50: 17nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50514164(CHEMBL4437065)
Affinity DataIC50: 17nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50514164(CHEMBL4437065)
Affinity DataIC50: 21nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50514164(CHEMBL4437065)
Affinity DataIC50: 426nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50514164(CHEMBL4437065)
Affinity DataKd:  2.41E+4nMAssay Description:Inhibition of spin-labelled adenine nucleotide interaction with human P-gp expressed in Escherichia coli BL21 (DE3) assessed as apparent dissociation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed