BDBM50530389 CHEMBL4438202

SMILES CNC(=O)c1cnc(NC(=O)C2CC2)cc1Nc1ccccc1S(C)(=O)=O

InChI Key InChIKey=YGFJMLGZTAWLOO-UHFFFAOYSA-N

Data  14 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50530389   

TargetNon-receptor tyrosine-protein kinase TYK2 [5-1181](Mouse)
TBA

Curated by ChEMBL

LigandBDBM50530389(CHEMBL4438202)Copy SMILESCopy InChI

Affinity DataIC50:  830nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetNon-receptor tyrosine-protein kinase TYK2(Human)
TBA

Curated by ChEMBL

LigandBDBM50530389(CHEMBL4438202)Copy SMILESCopy InChI

Affinity DataIC50:  1.60nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK2(Human)
TBA

Curated by ChEMBL

LigandBDBM50530389(CHEMBL4438202)Copy SMILESCopy InChI

Affinity DataIC50:  430nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
TBA

Curated by ChEMBL

LigandBDBM50530389(CHEMBL4438202)Copy SMILESCopy InChI

Affinity DataIC50:  310nMAssay Description:Inhibition of TYK2 JH2 domain in human whole blood assessed as inhibition of IFNalpha-induced STAT5 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
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TargetMast/stem cell growth factor receptor Kit(Human)
TBA

Curated by ChEMBL

LigandBDBM50530389(CHEMBL4438202)Copy SMILESCopy InChI

Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of cKIT (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
TBA

Curated by ChEMBL

LigandBDBM50530389(CHEMBL4438202)Copy SMILESCopy InChI

Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL

TargetMast/stem cell growth factor receptor Kit(Human)
TBA

Curated by ChEMBL

LigandBDBM50530389(CHEMBL4438202)Copy SMILESCopy InChI

Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of cKIT (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL

TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Human)
TBA

Curated by ChEMBL

LigandBDBM50530389(CHEMBL4438202)Copy SMILESCopy InChI

Affinity DataIC50:  390nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
TBA

Curated by ChEMBL

LigandBDBM50530389(CHEMBL4438202)Copy SMILESCopy InChI

Affinity DataIC50:  310nMAssay Description:Inhibition of TYK2 JH2 domain in human whole blood assessed as inhibition of IFNalpha-induced STAT5 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL

TargetNon-receptor tyrosine-protein kinase TYK2 [5-1181](Mouse)
TBA

Curated by ChEMBL

LigandBDBM50530389(CHEMBL4438202)Copy SMILESCopy InChI

Affinity DataIC50:  830nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
TBA

Curated by ChEMBL

LigandBDBM50530389(CHEMBL4438202)Copy SMILESCopy InChI

Affinity DataIC50:  1.60nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL

TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK2(Human)
TBA

Curated by ChEMBL

LigandBDBM50530389(CHEMBL4438202)Copy SMILESCopy InChI

Affinity DataIC50:  430nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL

TargetPotassium voltage-gated channel subfamily H member 2(Human)
TBA

Curated by ChEMBL

LigandBDBM50530389(CHEMBL4438202)Copy SMILESCopy InChI

Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL

TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Human)
TBA

Curated by ChEMBL

LigandBDBM50530389(CHEMBL4438202)Copy SMILESCopy InChI

Affinity DataIC50:  390nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL