BDBM50565717 CHEMBL4784431

SMILES COc1cc2ncnc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3)c2cc1OC

InChI Key InChIKey=LZSOTYFDFVIEGI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50565717   

TargetHepatocyte growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50565717(CHEMBL4784431)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant MET kinase domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50565717(CHEMBL4784431)
Affinity DataIC50: 17nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50565717(CHEMBL4784431)
Affinity DataIC50: 28nMAssay Description:Inhibition of c-KIT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50565717(CHEMBL4784431)
Affinity DataIC50: 87nMAssay Description:Inhibition of MET in human MKN-45 cells assessed as reduction in HGF-mediated autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50565717(CHEMBL4784431)
Affinity DataIC50: 111nMAssay Description:Inhibition of recombinant VEGFR2 kinase domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50565717(CHEMBL4784431)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed