BDBM50572099 CHEMBL4875615::US20260109697, Compound A57

SMILES Cn1cc(cn1)-c1ccc(CNc2cc(ncn2)-c2cnc3cc(OC4CCOC4)ccn23)cc1

InChI Key InChIKey=BKCVLCFRFPTZNP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50572099   

TargetMast/stem cell growth factor receptor Kit [V654A](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 50572099BDBM50572099(CHEMBL4875615 | US20260109697, Compound A57)
Affinity DataIC50: 11nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572099BDBM50572099(CHEMBL4875615 | US20260109697, Compound A57)
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant C-KIT V654A mutant (544 to end residues) using GGMEDIYEFMGGKKK as substrate measured after 40 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed