BDBM50572102 CHEMBL4871511::US20260109697, Compound A144

SMILES CN1CC(COc2ccn3c(cnc3c2)-c2cc(NCc3ccc(cc3)-c3cnn(C)c3)ncn2)C1

InChI Key InChIKey=DYMGRNVMAGSZDA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50572102   

TargetMast/stem cell growth factor receptor Kit [V654A](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 50572102BDBM50572102(CHEMBL4871511 | US20260109697, Compound A144)
Affinity DataIC50: 5.10nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572102BDBM50572102(CHEMBL4871511 | US20260109697, Compound A144)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant C-KIT V654A mutant (544 to end residues) using GGMEDIYEFMGGKKK as substrate measured after 40 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572102BDBM50572102(CHEMBL4871511 | US20260109697, Compound A144)
Affinity DataIC50: 61nMAssay Description:Inhibition of KIT (delta 560 to 576 residues) deletion/V654A double mutant autophosphorylation at Y703 in human GIST-430/654 harboring KIT (delta560 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed