BDBM50594435 CHEMBL5184876

SMILES CCS(=O)(=O)Nc1ccc(Oc2ccc(Cl)cc2)c(c1)-c1cn(C)c(=O)c2ccccc12

InChI Key InChIKey=LMYMWXJBPLXESU-UHFFFAOYSA-N

Data  6 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50594435   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594435(CHEMBL5184876)
Affinity DataKd:  3.60nMAssay Description:Inhibition of recombinant human BRD4-1 (44 to 168 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594435(CHEMBL5184876)
Affinity DataKd:  3.70nMAssay Description:Inhibition of recombinant human BRD4-2 (333 to 460 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBromodomain testis-specific protein(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594435(CHEMBL5184876)
Affinity DataKd:  6nMAssay Description:Binding affinity to N-terminal hexa-histidine tagged BRDT-T (2 to 416 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetBromodomain testis-specific protein(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594435(CHEMBL5184876)
Affinity DataKd:  5nMAssay Description:Inhibition of recombinant human BRDT-1 (21 to 137 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetBromodomain testis-specific protein(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594435(CHEMBL5184876)
Affinity DataKd:  12nMAssay Description:Inhibition of recombinant human BRDT-2 (250 to 382 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594435(CHEMBL5184876)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to BRD4-T (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB