BDBM50632105 CHEMBL5399624::US20260109697, Compound A222

SMILES Cn1cc(cn1)-c1ccc(CNc2cc(ncn2)-c2cnc3cc(OCCN4CCC(C)(CC4)C#N)ccn23)cc1

InChI Key InChIKey=ZPFXWSKRKHZIGJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50632105   

TargetMast/stem cell growth factor receptor Kit [V654A](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 50632105BDBM50632105(CHEMBL5399624 | US20260109697, Compound A222)
Affinity DataIC50: 17nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Merck Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632105BDBM50632105(CHEMBL5399624 | US20260109697, Compound A222)
Affinity DataIC50: 93nMAssay Description:Inhibition of KIT (delta 560 to 576 residues) deletion/V654A double mutant autophosphorylation at Y703 in human GIST-430/654 harboring KIT (delta560 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed