BDBM50632107 CHEMBL5405018::US20260109697, Compound A60

SMILES Cn1cc(cn1)-c1ccc(CNc2cc(ncn2)-c2cnc3cc(OCCN4CCCC4)ccn23)cc1

InChI Key InChIKey=FRTQGAQTCQQYJF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50632107   

TargetMast/stem cell growth factor receptor Kit [V654A](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 50632107BDBM50632107(CHEMBL5405018 | US20260109697, Compound A60)
Affinity DataIC50: 8nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Merck Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632107BDBM50632107(CHEMBL5405018 | US20260109697, Compound A60)
Affinity DataIC50: 70nMAssay Description:Inhibition of KIT (delta 560 to 576 residues) deletion/V654A double mutant autophosphorylation at Y703 in human GIST-430/654 harboring KIT (delta560 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed