BDBM50647995 CHEMBL5597392

SMILES OCCN1CCC[C@@H](Nc2nnc(-c3ccc4occc4c3O)c3c2C2CCC3CC2)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50647995   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50647995(CHEMBL5597392)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS/nigericin stimulated human PBMC assessed as reduction in IL-1beta release pretreated with LPS for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50647995(CHEMBL5597392)
Affinity DataIC50: 15nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS/nigericin stimulated mouse BMDMs assessed as reduction in IL-1beta release pretreated with LPS for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50647995(CHEMBL5597392)
Affinity DataKd:  18nMAssay Description:Binding affinity to human NLRP3 by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed