BDBM50666468 CHEMBL6177123

SMILES CCC(=O)Nc1ccc(NC(=O)c2ccc(C)c(C#Cc3cnc4cccnn34)c2)cc1C(=O)OC

InChI Key InChIKey=RRUTWBMGXWOUIU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50666468   

TargetPlatelet-derived growth factor receptor alpha(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666468BDBM50666468(CHEMBL6177123)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of wild type PDGFRA (unknown origin) extracted from Sf9 cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666468BDBM50666468(CHEMBL6177123)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of wild type His-tagged KIT (unknown origin) extracted from Escherichia coli BL21 (DE3) by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666468BDBM50666468(CHEMBL6177123)
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of His-tagged KIT D816H mutant (unknown origin) extracted from Escherichia coli BL21 (DE3) by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666468BDBM50666468(CHEMBL6177123)
Affinity DataIC50: 9.24E+3nMAssay Description:Inhibition of PDGFRA D842V mutant (unknown origin) extracted from Sf9 cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed