BDBM555304 Preparation of 4-((2-fluoro-6-methoxybenzyl)amino)-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-5-carboxamide::US11344549, Example 3

SMILES COc1cccc(F)c1CNc1nc(Cc2cnn(C)c2)ncc1C(N)=O

InChI Key InChIKey=DIBTVUWTGUFWBI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 555304   

TargetTyrosine-protein kinase JAK3(Human)
Beijing Scitech Mq Pharmaceuticals

US Patent
LigandPNGBDBM555304(US11344549, Example 3 | Preparation of 4-((2-fluor...)
Affinity DataIC50: 0.300nMAssay Description:JAK3 (the final concentration was 0.36 nM); ATP (the final concentration was 10 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Beijing Scitech Mq Pharmaceuticals

US Patent
LigandPNGBDBM555304(US11344549, Example 3 | Preparation of 4-((2-fluor...)
Affinity DataIC50: 0.570nMAssay Description:JAK2 (the final concentration was 0.25 nM); ATP (the final concentration was 5 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Beijing Scitech Mq Pharmaceuticals

US Patent
LigandPNGBDBM555304(US11344549, Example 3 | Preparation of 4-((2-fluor...)
Affinity DataIC50: 0.640nMAssay Description:TYK2 (the final concentration was 8 nM); ATP (the final concentration was 20 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Beijing Scitech Mq Pharmaceuticals

US Patent
LigandPNGBDBM555304(US11344549, Example 3 | Preparation of 4-((2-fluor...)
Affinity DataIC50: 2.81nMAssay Description:JAK1 (the final concentration was 10 nM); ATP (the final concentration was 10 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent