BDBM576066 4-(1-(1-(4-chlorophenyl)ethyl)- 2-methyl-1H-imidazo[4,5-b] pyrazin-6-yl)-6-methyl-1,6- dihydro-7H-pyrrolo[2,3-c] pyridin-7-one::US11466034, Example 21

SMILES Cc1nc2ncc(-c3cn(C)c(=O)c4[nH]ccc34)nc2n1C(C)c1ccc(Cl)cc1

InChI Key InChIKey=ZUZLUHIZHWXYHT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 576066   

TargetBromodomain-containing protein 4 [349-460](Human)
Betta Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 576066BDBM576066(4-(1-(1-(4-chlorophenyl)ethyl)- 2-methyl-1H-imidaz...)
Affinity DataIC50: 1.80nMAssay Description:The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [44-167](Human)
Betta Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 576066BDBM576066(4-(1-(1-(4-chlorophenyl)ethyl)- 2-methyl-1H-imidaz...)
Affinity DataIC50: 6.10nMAssay Description:The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent