BDBM612740 US11725005, Compound 102

SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncc(c3)-c3ccccn3)c2)CC1

InChI Key InChIKey=QGLVSYZUEILELT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 612740   

TargetMast/stem cell growth factor receptor Kit(Human)
Inhibikase Therapeutics

US Patent
LigandPNGBDBM612740(US11725005, Compound 102)
Affinity DataIC50: 6.70nMAssay Description:Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl22 mM DTT) and Stop buffer (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2023
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Inhibikase Therapeutics

US Patent
LigandPNGBDBM612740(US11725005, Compound 102)
Affinity DataIC50: 95.3nMAssay Description:Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl22 mM DTT) and Stop buffer (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2023
Entry Details
US Patent

TargetTyrosine-protein kinase ABL2(Human)
Inhibikase Therapeutics

US Patent
LigandPNGBDBM612740(US11725005, Compound 102)
Affinity DataIC50: 170nMAssay Description:Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl22 mM DTT) and Stop buffer (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2023
Entry Details
US Patent