BDBM612779 US11725005, Compound 116

SMILES CNC(=O)c1cc([nH]n1)-c1cncc(c1)-c1ccnc(Nc2cc(NC(=O)c3ccc(CN4CCN(C)CC4)cc3)ccc2C)n1

InChI Key InChIKey=RGUQJUZAJQPBOS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 612779   

TargetMast/stem cell growth factor receptor Kit(Human)
Inhibikase Therapeutics

US Patent
LigandPNGBDBM612779(US11725005, Compound 116)
Affinity DataIC50: 11.6nMAssay Description:Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl22 mM DTT) and Stop buffer (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2023
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Inhibikase Therapeutics

US Patent
LigandPNGBDBM612779(US11725005, Compound 116)
Affinity DataIC50: 91.1nMAssay Description:Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl22 mM DTT) and Stop buffer (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2023
Entry Details
US Patent

TargetTyrosine-protein kinase ABL2(Human)
Inhibikase Therapeutics

US Patent
LigandPNGBDBM612779(US11725005, Compound 116)
Affinity DataIC50: 161nMAssay Description:Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl22 mM DTT) and Stop buffer (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2023
Entry Details
US Patent